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doi: 10.2337/diabetes.50.2.227 99 TschpMSmileyDLHeimanML

XO donates electrons to oxygen and subsequently generate O 2 - and H 2 O 2 within the cell [34]

Epigenetic Modifications (DNA Methylation, Histone Modifications, miRNA Dysregulation) Beyond direct genetic mutations, toxins also induce heritable changes in gene expression through epigenetic reprogramming [37]

Thus, various tumors, including glioma, secondary glioblastoma, and acute myeloid leukemia (AML), harboring heterozygous point mutations in the active sites of IDH1/2 show dramatic increases in the R-2-HG levels 111,113,114,115

Each option has distinct mechanisms, benefits, and limitations

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