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implemented a transcriptomic- and proteomics-based approach and characterized 3 genes, MMP9, SPARC, and ITGA5 , to be associated with OSF pathogenesis (Shetty et al., 2025)

NADPH Oxidase-Derived ROS: Key Modulators of Heme-Induced Mitochondrial Stability in Human Neutrophils

Numerous lines of evidence have already shown the lack of functioning of DDR or DNA repair genes is linked to ALS development (36)

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TOX/TOX2 and NR4A13 function as central regulators that cooperate to establish and maintain an exhaustion program through chromatin remodeling and epigenetic stabilization ( Mechanistically, mitochondrial stress provides a plausible bridge between these states