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Taking a moderate, high-quality dose like 500 mg daily is generally more effective for long-term wellness than taking massive amounts sporadically
Note that pectin has been shown to bind vitamin B12 in the intestine making it less bioavailable 57

Gallogly et al., 2009
These findings suggest that high GSH intake correlates with poorer prognosis in breast cancer patients who underwent adjuvant chemotherapy

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Cellular localization, processing, and biochemical properties