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Upstream signaling proteins that stimulate the activity of mTOR include the Ser/Thr kinases, PKB/AKT, PI3K, and several members of the MAPK family of kinases

Additionally, GSTM2 -overexpressing mice showed mild LD accumulation in the first 3 weeks (Fig

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mitochondria), (2) matching the compartment (membrane, mitochondrial matrix, peroxisome) and (3) respecting the disease phase (acute hyper-ROS vs
