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This possibility is reflected in its clinical plasma half-life, which in the first-in-human study was measured to 85104 hours when administered at a dosage of 250 mg/kg [224]
Combined dosing tiers: Administer on an empty stomach
Hansen HH, Barkholt P, Fabricius K, Jelsing J, Terwel D, Pyke C, et al
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Animal studies show that direct BDNF infusion into the hippocampus produces antidepressant effects, while blocking BDNF signaling prevents antidepressants from working
