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However, if symptoms become severe or dont get better despite self-care, you should see a doctor especially in cases such as: Severe dryness with deep cracks, chronic peeling, or bleeding Pain when talking or eating, affecting daily life Darkened, hyperpigmented lips from chronic dryness that dont improve with lip balm Suspected underlying conditions such as eczema, diabetes, or a reaction to medications History of radiation therapy to the head and neck, causing persistent dryness Signs of infection: redness, burning, swelling, blisters, or pus Oral health issues such as unusually strong bad breath, frequent tooth decay, or recurrent gum inflammation If left untreated, cracked lips can progress to cheilitis, which may occur when bacteria or fungi enter through open fissures

Erratum in: Trends Biochem Sci

Additionally, medications such as saxagliptin and metformin have demonstrated effectiveness in regulating -cell function by reducing inflammation in newly diagnosed T2DM patients with PCOS (74).These findings suggest that the crucial role of pancreatic inflammation and -cell dysfunction in PCOS-related metabolic complications and highlight the need for targeted interventions that can improve -cell function and reduce inflammation