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The altered cy19a1 methylation pattern we measured in F1(F0-HFD) is absent in parental testis and thus likely appeared during embryo development as a consequence of trans-acting signals 55

Hassoba H, El-Sakka A, Lue T

This contrasted with the spared gross liver presentation, counteracted hepatomegaly and splenomegaly, reduced gross lesions in the stomach, duodenum and intestine, lower serum enzyme values, and no congestion of the central vein or branches of the terminal portal venules in BPC 157-treated rats

Informed consent was not applicable for this study

Acknowledgements This work was supported by grants SAF2015-71304-REDT and SAF2016-76520-R from the Spanish Ministry of Economy and Competitiveness