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193 In addition, Fusobacterium nucleatum can activate the RIPK1-mediated apoptosis pathway in UC, resulting in the destruction of tight junctions between cells, which in turn promotes the destruction of the intestinal barrier, inhibits the renewal of intestinal epithelial cells, and accelerates the progression of UC

Indication: As an adjunct treatment to minimize the occurrence of toxicity associated with cisplatin chemotherapy

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S., Lieberburg, I., Chaptal, C., & Krey, L

This local iron overload in DSCs triggers ferroptosis through reduced GSH and glutathione peroxidase four levels with the concomitant increase in lipid and cellular ROS

Glutathione recycling is catalyzed by glutathione disulfide reductase, which uses reducing equivalents from NADPH to reconvert GSSG to 2GSH