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Data from the National Survey on Drug Use and Health revealed that 80% of new heroin users previously abused prescription opioids, indicating a link between prescription analgesic misuse and heroin use.32 Tolerance significantly reduces the analgesic efficacy of opioids in patients with substance use disorders

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[DOI] [PubMed] [Google Scholar] 63.Frk W., Wojtasiska A., Lisiska W., Mynarska E., Franczyk B., Rysz J

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