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The most common genetic mutation causing SCD is the A to T transversion in the HBB gene on chromosome 11, leading to a substitution of valine for glutamic acid in the sixth codon [4] of the -globin protein chain and the production of sickle hemoglobin S (HbS)

Li J, Zhao S, Zhou X, Zhang T, Zhao L, Miao P et al

Gut Microbiota Modulation as a Novel Therapeutic Strategy in Cardiometabolic Diseases

These agents stabilize physiological function under stress via modulation of HPA tone, cAMP signaling, and cytokine balance

Oxidative stress is a part of many acute and chronic pathological processes in respiratory, cardiovascular, kidney, neurodegenerative, and biliary diseases, as well as in cancer

doi: 10.1016/j.mito.2016.12.006 163