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Results: The final review included six randomized controlled trials (Figure 1), summarized in Table 1

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In particular, under oxidative conditions, Nrf2 is released by its regulator Keap1, acquiring the ability to translocate in the nuclear compartment and to regulate the gene expression of the main antioxidant enzymes, deputed to the neutralization of superoxide and its derivates [106,107,108]

Regarding DML b (chr17: 34283701), ZNF136 (JASPAR ID: MA1588.1) can bind to the complementary region in the minus strand, but there is no evidence of its action on CCL11 expression