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Liu and colleagues employed cationic liposomes to deliver siRNA targeting ferritin in various tumor models, including glioma and breast cancer

Also, DNMT1 acts on hemimethylated DNA and maintains methylation patterns after DNA replication, where DNMT3a/3b performs a de novo methylation [10, 11, 20]

La RosaFClericiMRattoDOcchinegroALicitoARomeoMet al
NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1

This achieves subcellular targeting of therapeutics (e.g., PUE), mitigating MIRI-associated mitochondrial impairment
