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These microbiome changes reversed rapidly, however, when the obese mice were returned to a normal, lean diet 79

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5-Amino-1MQ is an oral NNMT (nicotinamide N-methyltransferase) inhibitor that works by blocking an enzyme that depletes cellular NAD+ and SAM

Although fundamental 5A-1MQ and LD-mediated changes to the microbiome were identified, this work is similar to many current studies where further investigations will clarify if changes in the microbiome are causative or associative 100

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