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This mechanism is supported by two key lines of evidence

Glutamine is the major inter-organ nitrogen transporter and regulator of acid-base balance

This process indicates that radiotherapy activates lung cells to undergo ferroptosis and induce RILI

Vitamin B6 also plays a role in essential enzymatic reactions for brain and cellular function

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Allosteric inhibition of phosphofructokinase-1 by citrate forms the basis of the Pasteur effect, the absence of which is critical for understanding the Warburg effect, i.e., aerobic glycolysis, a general feature of not just tumor cells 99 , but also healthy proliferating cells 100 such as lymphocytes and stem cells 101,102