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Research indicates that NNMT expression correlates positively with insulin resistance, with plasma levels of the NNMT product 1-methylnicotinamide associated with increased body mass index and metabolic dysfunction

Research has shown it to be effective in improving the healing of different wounds, including bone and muscle healing

Notably, GLS-mediated deamination of glutamine to glutamate is the first and rate-limiting step of glutaminolysis, making it an attractive druggable target 9

10.1038/s41598-024-76153-y

Administering carnitine to pigeons leads to reduced lactic acid production in muscles and prevents cramps

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