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Brain Activation Studies Neuroanatomical studies using c-Fos immunoreactivity (a marker of neuronal activation) mapped PT-141s central effects: Activation concentrated in hypothalamic nuclei including mPOA, paraventricular nucleus, and arcuate nucleus Limbic system activation in regions processing reward and motivation Dose-dependent activation patterns correlating with behavioral responses Selective activation in regions known to control sexual function across species Clinical Translation Gap: Despite robust preclinical evidence and successful Phase 3 trials in women, PT-141 currently has FDA approval only for premenopausal women with HSDD

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Mol Reprod Dev 49 : 343355 Whitin JC, Tham DM, Bhamre S, Ornt DB, Scandling JD, Tune BM, Salvatierra O, Avissar N, Cohen HJ 1998 Plasma glutathione peroxidase and its relationship to renal proximal tubule function