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Hyperhomocysteinemia Higher homocysteine levels are associated with a phenomenon called "methionine loading." A deficiency of Vitamin B12 along with B6 and folate usually prevents the conversion of homocysteine to methionine, increasing the levels of homocysteine

Activation of both striatal and PFC mGlu 2/3 may be involved in the observed suppression of psychomotor effects of stimulants, as intrastriatal mGlu 2/3 agonist administration reduces locomotor responses to amphetamine (Mao and Wang, 1999) and intra-PFC injection of the mGlu 2/3 agonist APDC attenuates locomotor activation by cocaine (Xie and Steketee, 2009)

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None of this constitutes evidence of efficacy

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