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10.1016/j.toxrep.2021.03.009

Future studies should develop time-resolved metabolic tracing technologies to uncover how metabolic heterogeneity drives degeneration in specific neuronal subtypes

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doi: 10.2310/JIM.0b013e31819d87c1

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are the key players contributing to oxidative stress generated intrinsically from normal cellular metabolism, and extrinsically, from environmental factors such as toxins, UV radiation, or cigarette smoke (Forman and Zhang, 2021)

(2022) developed an ex vivo culture system that utilized synthetic extracellular matrices (sECMs) to partially mimic properties of extracellular matrix in vivo