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Curr Med Chem 12:1161208, PMID: 15892631 Morris G, Maes M (2014) Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways

However, we also find that non-metazoan sequences typically display more variability, particularly for subfamilies, PRX5 and PRX6

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Afterwards, the statistical significance of the model can be evaluated by permutation testing to assess the lack of overfit