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It is generally well-tolerated, with the following side effects [9][18]: GI symptoms (most common): Nausea, vomiting, diarrhea, and abdominal discomfort, particularly at doses above 1,200 mg/day Sulfurous taste/smell: NAC has a distinct sulfur odor and taste that some find unpleasant Headache: Occasionally reported Anaphylactoid reactions (IV use only): Infusion-related reactions including flushing, itching, bronchospasm, and hypotension occur in approximately 10-20% of patients receiving IV NAC for acetaminophen overdose [18] Upper limit: There is no established UL for NAC

Biochem Biophys Res Commun 289 : 8084

Kim JW, Moon AR, Kim JH, Yoon SY, Oh GT, Choe YK, et al

Consequently, damage to tubular epithelial cell damage may be an essential link in the development of renal damage associated with hyperuricemia (HUA)

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Topographic gradients of intrinsic dynamics across neocortex