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Acknowledgements The authors acknowledge Hexiang Mei for providing advice in experimental methodology design

Recognition of P1 and P2 residues The S1 subsite is sufficiently deep to accommodate the bulky Tyr side chain of the bound dipeptide (Fig

3 Opportunities for Pharmacotherapies to Address MUD Withdrawal and Relapse Risk In addition to the development of maintenance therapies for MUD, opportunities exist to consider pharmacotherapies that address acute withdrawal from methamphetamine and the more protracted neurobiological changes that can persist for weeks to months thereafter

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doi: 10.1016/j.tplants.2016.09.002 60 MouralT

Too much glutamate may lead to brain cell death