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The most common triggers are stress, fatigue, anxiety, exercise, and caffeine consumption (Jafer Chardoub AA, Patel BC)

no controlled trials have directly compared continuous vs cyclic dosing in healthy adults

10.1016/j.lfs.2017.12.025 37 CutlerP

Moreover, BH4 prevents ferroptosis by producing CoQH2, inhibiting LPO, and scavenging free radicals (Zhang G
