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The Key Factors in the Methylation Cycle We will now consider three important causes of interruption to the methylation cycle: Vitamin B12 deficiency Folate deficiency MTHFR mutation Vitamin B12 deficiency If vitamin B12 is deficient, the methyl group cannot be transferred from methylfolate to the methionine cycle
The distinction matters
Abbasi, G
M., Sheftic S
Only then can a regulatory submission be prepared followed by an independent review by agencies such as the EMA or FDA
But its major limitation
