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A 20-year-old female with polyarteritis nodosa developed sudden bilateral sensorineural hearing loss throughout the entire frequency range, tinnitus, and vertigo with nausea and vomiting 25 minutes after receiving 30 mg of intravenous ketorolac

Because it is a small molecule and not a fragile peptide chain, 5-Amino-1MQ exhibits excellent membrane permeability and oral bioavailability

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While there is no corroborative clinical trial data, animal experiments suggest that hydroxocobalamin produces a time and organdependent, selective regulation of nitric oxide synthases during endotoxemia and regulates downstream inflammatory mediators, thereby having a potential role in the treatment septic shock 4

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