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74 The enhanced oxidant stress in the mitochondrial matrix is then mainly derived from complex I and, to a lesser degree, from complex III, 71 and the oxidant stress and injury correlate with protein adduct formation in mitochondria

Further, the study was also designed to test the homocysteine theory of depression, ie, circumventing the patients genetic inability to metabolize B vitamins by administering the metabolized forms in an optimal preparation for CNS availability would lower homocysteine, increase monoamine production, and facilitate clinical improvement

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Oncogene 17:24732484 Huang C, Hatzi K, Melnick A (2013) Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms