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Amid concerns of losing its first-mover advantage to competitors like Eli Lilly, the company also saw a change in leadership with the ousting of its CEO in May 2025

Retatrutide is still investigational and not approved by any regulator as of April 2026, so everything below is presented as clinical-trial data, not as medical guidance

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Lifestyle factors such as a healthy diet, regular exercise, and stress management can also significantly impact longevity

Overseas sellers extracted the retatrutide formula from Lillys own patent filings and scientific papers, then began marketing it under names including Reta, GLP-3, Triple G, and, tellingly, ratatouille, all before Lilly finished safety testing and despite explicit FDA warnings that such sales are illegal (more on Bloomberg)

While most adverse effects observed have been manageable, certain patient profiles present a higher risk for complications and should be screened carefully before treatment initiation