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These reversible modifications are playing essential roles in gene regulation, X-inactivation, imprinting, and silencing of parasitic DNA elements ( PATHOLOGICAL ALTERATIONS OF GSTP1 METHYLATION PATTERNS DNA methylation, the addition of a methyl-group to cytosines is the most common epigenetic modification, inducing the reorganization of the gene locus and thus regulating gene expression (Smith and Meissner, 2013)
In specifically, the Mn-SOD ratio (levels in normal and malignant tissue) is demonstrated as an independent predictive indicator in patients of gastric cancer, and it appears to be therapeutically relevant for the survival of patients, the higher the ratio, the poorer overall survival (163)

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