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This is prevalent in the glutathione S-transferase (GST) family of genes

Deshmukh, M., Kutscher, H., Stein, S

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In DPPOS year 9, vitamin B 12 deficiency rates were 4.4%, 5.9%, and 4.9% for GG, AG and AA genotype groups in the placebo arm, vs 5.7%, 6.6%, and 18.7% in those respective genotype groups in the metformin arm (ESM Table 9)

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an intellectual Property License Agreement was signed with DSM, which provides exclusive use of pharmaceutical claims under patent rights in China, Mexico, Japan, Canada, and Europe