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Gastroenterology Hepatology 31 (11), 13421349

Increased GSH levels and GCLC transcription and mRNA levels (GCLM expression was unchanged) also occur in human hepatocellular carcinoma (HCC) [26]

Thus, targeting the CR3 domain may be better than the FH domain of FOXO4 for blocking the binding of TP53 to FOXO4

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Consequently, therapeutic strategies to modulate ferroptosis, either as inducers to eradicate cancer cells or as inhibitors to protect neurons or ischemic tissues, have unfolded as a promising avenue of translational research

Persistent inflammation and cigarette smoke are primary sources of ROS in the lung, causing redox imbalance and peroxidation damage to lipids, proteins, and nucleic acids ( in vitro