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Interestingly, the reduction of IGF-1 was observed irrespective of the weight loss, suggesting that IGF-1 downregulation precedes cachexia development

PLoS One 10:e0130251 Afshar B, Ganjalikhani-Hakemi M, Esfahani ZK, Eskandari N, Shaygannajad V, Hosseininasab F, Alsahebfosoul F (2021) Evaluating the effects of epigallocatechin-3-gallate on HIF-1 protein and rorc gene expression in peripheral blood mononuclear cells in patients with multiple sclerosis

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