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The increase in the number of aromatisation sites in these patients causes increased androgen to oestrogen conversion, with low bioavailable testosterone and high serum estradiol levels 54
serious complications are rare
Similarly, the histone demethylase KDM3B prevents ferroptosis through ATF4-dependent upregulation of SLC7A11 [85]
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In breast cancer cells, luteolin activates ERK and p38 MAPK pathways, and their inhibition or knockdown reduces luteolin-induced cell death, while caspase-3 inhibition has no effect
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