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When monoglutamate folates are taken up into cells, particularly in the liver and kidney where they can be stored (but also in other cells), they are polyglutamated through the action of the enzyme folylpolyglutamate synthase

BhatGRSethiISadidaHQRahBMirRAlgehainyNet alCancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance

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[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Topalian SL, Forde PM, Emens LA, Yarchoan M, Smith KN, Pardoll DM

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Neutrophil apoptosis is a critical step for inflammation resolution