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Common signs of B12 deficiency include fatigue, weakness, pale skin, shortness of breath, numbness or tingling in the hands and feet, difficulty maintaining balance, and cognitive issues like memory problems

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HLCs derived from the small molecule protocol showed a dedifferentiated, proliferative phenotype that is more akin to liver tumor-derived cell lines

Overall, the MD data was consistent with the markedly different dynamics observed in the cryo-EM 3DVA with the ECDs undergoing substantially greater dynamic motions in the Cagri-AMY 3 R complex than observed in the parallel rAmy-AMY 3 R complex (Supplementary Fig

5i) presented significantly shorter escape latencies than did the control group