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At lower doses, none of the drugs affected Zo1 expression, preserving BTB integrity, whereas amitriptyline downregulated Zo1 expression at higher doses, indicating BTB damage (Yuan et al., 2020)

This results in the release of stress mediators such as endocrine hormones, cytokines, and neurotransmitters

[PMC free article] [PubMed] [Google Scholar] 42.Mauvais-Jarvis F, Lange CA, Levin ER

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The current understanding is purely speculative, based on preclinical data for MOTS-c and clinical trial data for Retatrutide as monotherapy