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Structure, Function, and Post-Translational Regulation of the Catalytic and Modifier Subunits of Glutamate Cysteine Ligase

Ebselen was found to increase the expression of GPX1 in SGNs after peroxynitrite damage, which is consistent with the reports that ebselen can increase the expression of GPX1 in cochlea after electrical stimulation ( gpx1 / mice leads to the aggravated SGN injury (cell loss and apoptosis) induced by peroxynitrite, although it might cause no effect on SGN development as SGNs presented normal morphology and cell number in gpx1 -deficient mice

upon oxidative stress, Trx oxidation releases ASK1, permitting its oligomerization and activation [69]

VenketaramanVDayaramYKAminAGNgoRGreenRMTalaueMTet al

Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice

J Clin Invest (2017) 127(7):2492504