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Although repurposing existing drugs offers a cost-effective and time-efficient alternative for identifying new therapies, their effective concentrationsmeasured as the half-maximal inhibitory concentration (IC50)often exceed the maximum safe plasma levels in humans, creating a major barrier to clinical application

Neurosurgery (1993) 33:6108

and Yang and Raner showed in their studies the controlling effect of green tea in the statement of P450 cytochrome [21, 22]

Abuse liability of mitragynine assessed with a self-administration procedure in rats