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Abbreviations CVD: Cardiovascular disease CHD: Congenital heart disease AAA: Abdominal aortic aneurysm TAD: Thoracic aortic dissection CAD: Coronary artery disease Hcy: Homocysteine HHcy: Hyperhomocysteinemia CBS: Cystathionine -synthase MTHFR: 5,10-Methylenetetrahydrofolate reductase ECs: Endothelial cells VSMCs: Vascular smooth muscle cells HUVECs: Human umbilical vein endothelial cells HASMCs: Human aortic smooth muscle cells ECM: Extracellular matrix MMPs: Matrix metalloproteinases PDGF: Platelet-derived growth factors References Zaric BL, Obradovic M, Bajic V, Haidara MA, Jovanovic M, Isenovic ER (2019) Homocysteine and hyperhomocysteinaemia

GST8 RNA levels were strongly induced by 2,4-D and NAA (two synthetic auxins) and by IAA (Bianchi et al

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Increased ROS levels and inhibition of ROS scavenging mechanisms render the cells vulnerable to subsequent oxidative stress and further DNA damage which triggers the DNA-damage response mechanisms