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This integrated tri-agonist approach produces synergistic metabolic effects that cannot be achieved with other research peptides: Source: Jastreboff et al., New England Journal of Medicine, 2023 Source: Killion et al., Nature Metabolism, 2022 Source: U.S

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25 Besides the aforementioned NNMT inhibitors through a ligand-based discovery, high throughput screening has led to the identification of JBSNF-000088 ( 4 ) that inhibited hNNMT, monkey NNMT, and mouse NNMT enzymatic activities with IC 50 values of 1.8, 2.8, and 5.0 M, respectively