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In 2011, Kakkar and Kaur introduced spanlastics, a non-immunogenic, biodegradable system that delivers medications via various routes, including oral, topical, nasal, and transdermal methods 29

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Besides this, the NPs could be easily engineered for specific targeting and the potential to improve drug bioavailability and efficacy (84)

Studies have demonstrated heterogeneity in PDAC metabolism, which implies differences in tumor metabolic preferences among different patient sources or at different spatial and temporal states of the same patient 14