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The safety of glutathione depends fully on the clinical process

Introduction Tuberculosis (TB), a communicable disease caused by Mycobacterium tuberculosis (Mtb), remains a major public health challenge ( Intracellular glutathione (GSH) level has been pointed as an important biomarker in HIV infection ( Besides NAC effects on Mtb growth, several studies have suggested this drug as an important modulator of host cell biology and immune response ( Recently, we have reported a clinical trial conducted with hospitalized HIV/TB patients in Brazil in which we evaluated the safety of NAC and its efficacy in accelerating mycobacterial clearance in sputum cultures ( Methods Ethics Statement The study was approved by the Ethics Review Committee of Fundao de Medicina Tropical Dr Heitor Vieira Dourado (FMT-HVD) (protocol study number: 60219916.5.0000.0005)

634 Thus, understanding zinc intake recommendations and the efficiency of different zinc compounds for supplementation is crucial to fully optimize the benefits of zinc for various demographic groups

Its downregulation may impair cellular stress management, promoting protein aggregation and cellular dysfunction, which contribute to PEXS pathogenesis (Hayat et al., 2020)

This aligns with the mechanistic literature

However, the studies mentioned above highlight its significance in AS and offer new insights for investigating the pathological mechanisms of AS through ferroptosis