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Because of global aging, the prevalence of pain, depression, and comorbid pain and depression is expected to increase (Molton and Terrill, 2014

However, it can be a helpful supplement for athletes who are looking to improve their endurance and performance

These conditions are discussed in Chapter 12

Afamelanotide helps increase the amount of pain-free time a person with EPP can spend in artificial light or sunlight

Does not contain: Starch, corn, milk, wheat, yeast, sugar, eggs, salt, artificial colors, binders, flavors, preservatives, or fish derivatives

Its protective effects were due to increased expression of Cu/Zn superoxide dismutase (SOD-1) and other antioxidant enzymes, basic fibroblast growth factor, insulin-like growth factor 1, epidermal growth factor, and hepatocyte growth factor