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Consult your doctor before trying unproven therapies and never use them as a replacement for conventional treatments

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Two ongoing phase I, randomized, double-blind, placebo-controlled trials are ongoing and aim to evaluate safety, tolerability and target engagement of DNL151 in healthy volunteers (NCT04557800) and PD patients (NCT04056689)

The state of ketosis, induced by low insulin levels, may generally benefit cancer patients, as KBs have been shown to inhibit glycolysis in various tumor cell lines 73, 74 and probably also patients, 75, 76, 77 and tumor cells often lack the enzymes 78, 79, 80, 81 or oxygenation 82 to effectively use ketones for energy production

Another potential risk factor that may be present in an increasing number of patients is hepatic steatosis or steatohepatitis caused by obesity, type 2 diabetes, and poor diet [180]

However, as in the ongoing Phase I clinical study, the anti-tumor immune activity of ES014 requires further clinical trial support, despite its good tolerance in cynomolgus monkeys