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Dependent on the form of ADT used, build-up of steroid precursors occurs that are shunted to the synthesis of other steroids, such as progesterone (e.g., treatment with CYP17A1 inhibitor abiraterone), some of which can stimulate CaP progression via co-occurring accommodating changes in AR [35]

However, further mechanistic studies are needed to determine the direct effects of choline availability on eosinophil activation and function and to assess the therapeutic potential of dietary choline supplements (95) in managing hyperreactive eosinophilic conditions, such as eosinophilic myositis or gastrointestinal disorders

For participants with only one baseline TMAO measure (17%), that measured was carried forward

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