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However, it is not known whether NADPH produced by NNT is present just to detoxify ROS because NADPH may be exported to the cytoplasm as isocitrate via the reaction catalysed by mitochondrial NADP-dependent isocitrate dehydrogenase (Fig

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10.1016/j.yjmcc.2011.10.011 [DOI] [PMC free article] [PubMed] [Google Scholar] Lee J., Lim J

Recently, the addition of green tea catechins to dentifrice has shown reduction of periodontal inflammation in the rat model, by decreasing gingival oxidative stress and expression of pro-inflammatory cytokines [28]

Also, duringPhase 2, 4 children dropped out due to adverse effects, with 2 of those children being on DMSA, and 2 being on placebo