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McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia

This may lead to deficits in long-term potentiation at central excitatory synapses and contribute to cognitive impairments and epilepsy in Rett syndrome (160)

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In the present study, evaluation of the core sequences confirmed this in 12/18 (66.7%) samples that were not detected by the GT Plus but classified as subtype 1b by sequencing (for another sample sequencing failed)

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

The trial data (STEP 4) supports continued therapeutic dosing