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Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via AP-1 and NFB

The antioxidant capacity can be evaluated by looking at the enzymes superoxide dismutase and catalase

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While these results cannot be directly extrapolated to human pulmonary hypertension patients, they suggest BPC-157 may influence the vascular remodeling processes that underlie this condition