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Lan K, Luo MH

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This is explained by the toxic effect of lactate accumulating due to the reduced activity of the pyruvate dehydrogenase complex, overproduction of free radicals and oxidative stress, and changes in the microglia at the onset of neurodegeneration [5458]

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235, 236 In addition, a decrease in the sensitivity of cancer cells to the cytostatic/cytotoxic effects of CDDP has been associated with the upregulation of microRNAs that target the major oncosuppressive factor phosphatase and tensin homolog (PTEN), such as miR-130a and miR-93, 240, 241 and ERCC1, like miR-138, 237 as well as with the downregulation of microRNAs that normally limit the expression of cell cycle-associated proteins such as let-7b