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Exon 12 skipping in FPGS gene results in dysfunctional FPGS which leads to the inhibition of anti-folate drugs such as methotrexate and introduces resistance in acute lymphoblastic leukemia [68]

In parallel, copper sulfide (CuS) nanoparticles, with strong near-infrared (NIR) absorption and efficient photothermal conversion, can convert NIR light into heat to induce direct tumor ablation

In another study, where lycopene was administered at 25 and 50 mg/kg body weight for 3 months to male Wistar rats, results showed increased HDL, improved antioxidant, and oxidant biomarkers, decreased triglycerides (TG), LDL, apolipoprotein-B (Apo-B), and -hydroxybutyrate, but boosted hepatic PPARG levels [80]

This state can be observed in mammals as a means of surviving periods of reduced resource availability or adverse meteorological conditions

Natelson BH

J., Mullin, J