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DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide, first identified in mammalian brain tissue in the 1970s

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[10] In living organisms, the process is normally catalyzed by enzymes known as peptidases or proteases, although there are reports of peptide bond hydrolysis caused by conformational strain as the peptide/protein folds into the native structure

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Both of these techniques allow the physician to view the end of the esophagus and determine whether or not the normal lining has changed

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