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Neural stem cells (NSCs) are multipotent and are present in the sub-ventricular zone (SVZ) of the forebrain and the subgranular zone (SGZ) of the hippocampus [137]

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Indeed, stimulation of NMDARs, expressed in immature and mature oligodendrocytes, promote the maturation of these cells and myelination around axons [181,182,183], up-regulates their energy metabolism, increases mitochondria motility within myelin sheath, and glycolytic support to the axons [184, 185]

doi: 10.1017/S0031182005007316

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This effect was enabled by activating the p75NTR and TrkA receptors and the upstream MAP/ERK signaling pathway